Extends Relieving efficacy in Short – term treatment of Major depressive disorder
desvenflaxine 50 and 100mg/d demonstrate antidepressant, safety, and tolerability

Major depressive disorder with clinically relevant Anxiety symptoms
50mg/day significantly improves depressive symptoms in major depressive disorder patients with clinically relevant anxiety symptom

Reduces frequency and Severity of Menopausal Hot Flashes When Other treatment fail
Frequency of hot flashes reduced by 55-69%
– Good safety and tolerability profile in titrating

Optimum dose-100mg/day Started at 50 mg/day for 3 days and titrated to 100mg/day

Relieves pain associated with Diabetic peripheral neuropathy
Effective in relieving pain associated with DPN at doses of 200 and 400 mg/day.
Improves activity impairment
Generally well tolerated in short term & long term studies